In the episode "Dorado Falls", Max Martini guest-starred as Luke Dolan, a former U.S. Navy Seal suffering from posttraumatic stress disorder and capgras syndrome who goes on a murderous rampage.

In the episode "Painless", Eric Jungmann guest-starred as Robert Adams, a survivor of a high school shooting who copied the murders committed by Randy Slade.

In the episode "Hope", Brigid Brannagh guest-starred as Monica Kingston, a mother whose daughter was abducted and murdered by Bill Rogers, played by Jack Coleman.

In the episode "Self-Fulfilling Prophecy", René Auberjonois of Star Trek: Deep Space 9 fame guest-starred as Colonel Ronald Massey, the leader of the Somerville Military Academy and criminal accomplice of both his second in command and of a dead cadet's vengeful father.

In the episode "Unknown Subject", Jay Karnes guest-starred as Hamilton Bartholomew, aka "The Piano Man", a serial rapist who is assaulting the victims he previously raped.

In the episode "A Thin Line", Paul Johansson guest-starred as Clark Preston, a mayoral candidate and criminal accomplice of hate crime serial killer Trevor Mills.

In the episode "The Company", Shanola Hampton guest-starred as Cindi Burns, Derek Morgan's cousin who suffered from stockholm syndrome after marrying and giving birth to the son of her abductor, Malcolm Ford.