The river rises in the 342,192 hectares (845,570 acres) Nascentes da Serra do Cachimbo Biological Reserve, a strictly protected conservation unit established in 2005 in the state of Pará.

[1] After crossing the border into Mato Grosso the river flows through the 184,900 hectares (457,000 acres) Cristalino State Park, established in 2001, before entering the Teles Pires.

The river is navigable throughout the state park, despite the large number of submerged rocks and small rapids along its course.

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