Vice-president of La Prensa, she was an aspiring presidential candidate in the 2021 Nicaraguan general election until the Ortega government disqualified her from running and ordered her arrest in early June 2021.

Her father, a critic of the Somoza regime, was murdered in 1978, turning the tide of support against the dictatorship which fell to the Sandinista National Liberation Front the following year.

She served in this capacity until January 2021,[9] and in February 2021 the Foundation ceased operations after the Ortega government, which had returned to power in 2007, announced a new law that all groups receiving funding from outside Nicaragua would be required to register as foreign agents.

[10] Prior to being put under house arrest, Chamorro was a pre-candidate for president of Nicaragua, supporting a unified opposition ticket to challenge incumbent Daniel Ortega, who was running for a fifth term.

[11] The day Chamorro was called in for questioning, the police also raided the news offices of her brother Carlos's media channel, Confidencial, confiscating equipment and arresting a cameraman.