His daughter, María Dolores Alemán Cardinel, served as First Lady of Nicaragua from January 1997 until October 1999 under her father.

[1][2] In October 1999, President Alemán married María Fernanda Flores Lanzas, who then assumed the role of first lady.

[1][2] The incumbent first lady is Rosario Murillo, the wife of President Daniel Ortega, who has held the position since 2007.

Murillo had previously served as first lady during the 1980s as Ortega's domestic partner in a common-law marriage.

[8] In 2021, Ortega, who was seeking a fourth consecutive term, and Murillo were re-elected during an election marred by the arrest and detention of numerous political opponents of the Ortega government, including Cristiana Chamorro Barrios, the first lady from 1990 to 1997, and María Fernanda Flores Lanzas, the former first lady from 1999 to 2002.