He has worked both in the public and private sectors and has collaborated with Paris-Sorbonne University, French Academy in Rome, Electa, the Roman National Museum, the Spanish Embassy in Italy, the Bath of Caracalla, and the Centre des Monuments Nationaux - Cité internationale de la langue française.

Under his leadership the Santa Maria della Scala Foundation initiated a significant expansion of its corporate structure, proposing the inclusion of the Ministry of Culture and the Universities of Siena as new stakeholders.

Through this multifaceted strategy, Cristiano Leone has successfully positioned Santa Maria della Scala as a dynamic institution that honors its rich heritage while embracing contemporary cultural dialogues.

He has taught courses in Linguistics and Philology at the University of Namur, in Humanities, History, Artistic Direction[12] and Performance Art[13] at Sciences Po in Paris, and in Cultural Programming at the LUISS Guido Carli Business School in Rome.

This edition, more extensive, also occupied the Palazzo Altemps and staged among other things a tribute to Fellini by violinist Yury Revich,[20] Pierre Yovanovitch, and the danseur étoile Benjamin Pech.

In this film, they confront two masterpieces of the Italian Baroque: the sculptures Apollo and Daphne and The Rape of Proserpina by Gian Lorenzo Bernini, inspired by Ovid's Metamorphoses.

RADIX III deals with highly topical issues, such as the abuse of power, the boundary between consent and refusal, the entanglement of desire, domestic violence, rape, and kidnapping, as well as artistic representations of those themes throughout the centuries.

As the second chapter of this artistic project, entitled Mysterion, it was conceived as a celebration of the underground areas of that vast monumental complex and its ancient Mithraeum, which, after many centuries, again welcomed the ritualism of the cult of Mithras, though in a contemporary mode.

[34] On 15 April 2024, the Water Mirror at the Baths of Caracalla was inaugurated, a project conceived by Cristiano Leone in collaboration with architect Hannes Peer and in dialogue with the site's director.

This permanent installation marked the return of water to the ancient Roman baths after approximately 1,500 years, transforming the space into a dynamic platform for cultural events.

The Water Mirror not only enhances the visual grandeur of the ruins by reflecting their monumental architecture but also serves as a stage for performances, conferences, and artistic events.

Its inaugural event featured a performance of "Rhapsody in Blue" by Aterballetto Danza sull’Acqua, celebrating the fusion of historical heritage with contemporary art.

[35][36] He co-authored an open letter to Angela Merkel, François Hollande and Matteo Renzi on the importance of cultural and youth policies to rebuild a European identity, alongside Wim Wenders, Felipe González, and other intellectuals.

For the Institute for International Political Studies (ISPI) he wrote an open call to create a large-scale Italian festival aimed to promote the dialogue between contemporary creation and historical heritage.

[39] Cristiano Leone is the author of the program "Il giorno della Libertà" for the Italian national channel Rai 3, broadcast on the occasion of the 30th anniversary of the Fall of the Berlin Wall.