Vee's roles in anime include Louise in The Familiar of Zero, Nanoha Takamachi in the Magical Girl Lyrical Nanoha series, Mio Akiyama in K-On!, Noel Vermillion/Mu-12, Nu-13, Saya, and Lambda-11 in the BlazBlue series, Nagisa Saitō in Squid Girl, Homura Akemi in Puella Magi Madoka Magica, Compa and Croire in Hyperdimension Neptunia, Rei Hino / Sailor Mars in the Viz Media dub of Sailor Moon, the Honoka sisters in Knights of Sidonia, Hawk from The Seven Deadly Sins, Darkness in KonoSuba, Thoma in The Promised Neverland, Meiko Mochizuki in Digimon Adventure tri., Killua Zoldyck in Hunter × Hunter, Yuko Tani in Godzilla: Planet of the Monsters, Godzilla: City on the Edge of Battle, and Godzilla: The Planet Eater, Vivy in Vivy: Fluorite Eye's Song, Robyn Hill in RWBY, Sakura Matou in Fate/stay night: Heaven's Feel, Fate/stay night: Unlimited Blade Works, and Fate/Zero.

She was the co-host of AnimeTV with Johnny Yong Bosch[2] and portrayed Haruhi Suzumiya in the live-action The Adventures of the ASOS Brigade.

She also voices Verosika Mayday in the adult animated web series Helluva Boss and Fwench Fwy in Chikn Nuggit.

[7] Cristina studied theatre arts and graduated from California State University at Long Beach in 2007 where she took classes with Professor Hugh O'Gorman, who supported her career goals.

Because of depression and panic attacks, there were a couple of years where it was extremely hard for me to go to classes.”[7] When Vee was younger, she wanted to become an animator, but after watching Sailor Moon, she was inspired to become a voice actor.

In 2004, she joined a voice-over panel where she helped work some of the equipment and then got a card from Wendee Lee to audition for several shows with Bang Zoom!

[26] In 2015, she voiced Noel Vermillion in BlazBlue Alter Memory, Compa in Hyperdimension Neptunia: The Animation, and Hawk in The Seven Deadly Sins, the last of which was released as a Netflix original series.

[37] In 2015, Vee began voicing Marinette Dupain-Cheng/Ladybug in the English dub of the animated series Miraculous: Tales of Ladybug & Cat Noir.

[40] In 2021 and 2024, Vee voiced Verosika Mayday in the animated web series Helluva Boss, starring in the episodes "Spring Broken", Ozzie's" and "Apology Tour".

[41][42] Vee has been involved in voice-overs for video games, mostly with English localizations of Japanese titles produced by Atlus USA and NIS America.

Some of her major roles are Noel Vermillion in BlazBlue, Velvet Crowe in Tales of Berseria, Riven the Exile in League of Legends, Four in Drakengard 3, Compa in Hyperdimension Neptunia, 13-Amp and 5-Volt in the WarioWare series, Marnie in Pokémon Masters EX, the title character of the Shantae series[22][43] and her arch-nemesis Risky Boots, as well as Bennett and Xingqiu in Genshin Impact.

[44][45] In addition to performing live as Haruhi Suzumiya, Vee has appeared on screen on various web series, television shows and events.

In April 2024, Vee released a cover of "Whatever It Takes" from the Prime Video animated series Hazbin Hotel (set in the same fictional universe as Helluva Boss), featuring content creator, cosplayer and voice actress Sofia Gomez and musician Tre Watson.