Cross dehydrogenative coupling

Cross dehydrogenative coupling (also known as CDC reaction), coined by Chao-Jun Li of McGill University,[1][2][3][4] is a type of coupling reaction allowing the construction of a carbon–carbon bond[5] or C-Heteroatom bond[6] directly from C-H bonds in the presence of an oxidant, leading to the thermodynamically unfavorable formal removal of a H2 molecule.

As such, CDC are couplings belonging to the C-H activation strategy.

Therefore, the CDC reaction has the advantages of high efficiency, Atom economy and environmental friendliness.

The mechanism and reactivity of the CDC reactions varies dramatically depending on the substrate.

[9][10] The synthesis and functionalization of various nitrogen, oxygen and sulfur-containing heterocycles have also been achieved via CDC.