Crucifix of San Marcello

According to popular belief at the time, the procession caused the plague to leave the neighborhoods through which the crucifix passed, and eventually to die out in Rome.

The scholar Daniel McCann notes that when the plague reached Rome in 1522, it took hold of the popular imagination to the extent that many blamed Pope Adrian VI for the outbreak.

However, some Catholics made a 16-day procession with a crucifix from S. Marcello al Corso, through the streets of Rome, to St Peter's Basilica.

[11] Because the crucifix[2]—although deformed by the heat[9]—had survived the flames, it was believed to possess thaumaturgical powers, a belief that was further enhanced by its perceived role in ridding the city of plague in 1522.

McCann notes, however, that unlike other crucifixes in Rome—which are ubiquitous on account of the importance the symbol plays in Christian theology—this one possessed "darker tones and hues" than most.

Although almost certainly a myth, argues McCann—probably designed to boost the object's reputation—it illustrates how, to the medieval popular imagination, plague and healing, life and death were inextricably linked in the crucifix.

[2] In response to popular clamour, Cardinal Raimondo de Vico arranged a penitential procession from San Marcello to St Peter's.

[13] This was a particularly bold move, suggests McCann, reflecting the desire of the citizenry who remained in Rome to be proactive rather than merely await death quietly.

[13] According to contemporary chroniclers, the reason for the long duration of the procession despite the relatively short distance between the church and the Vatican was that each district attempted to delay the crucifix due to the good it was doing.

[13][note 5] The crucifix itself was protected, venerated and its stories promulgated by its sodality, which also limited physical access to it in order to heighten the mysticism surrounding it.

[5][6] The Pope blessed Rome in what The Art Newspaper describes as a "scene of great dramatic power, at dusk, under driving rain, and facing the vast emptiness of St Peter’s Square".

[19] The crucifix was again utilised on 27 March 2020 in an urbi et orbi prayer in St Peter's Square,[note 8] which was empty due to the Italian COVID-19 lockdown.

[19] Delumeau suggests that study of the S. Marcello crucifix allows scholars to trace the development of popular religious sentiment in 16th century Italy.

[21] It was also the basis for future Papal processions against plague and heresy,[22] themselves an expression of the general tendency of greater popular piety following the Council of Trent.

Interior of the Oratory of Santissimo Crocifisso illustrating its murals and crucifix
Procession of the Crucifix Against the Plague of 1522
Paris Nogari , Procession of the Crucifix Against the Plague of 1522 (1583–84), Oratorio del Crocifisso fresco [ 12 ]
External view of the Oratory in 2009
External view of the Oratory of Santissimo Crocifisso where the cross is in place today