These bundles and fascicles give rise to thin filaments known as Purkinje fibers.

The ventricular conduction system comprises the bundle branches and the Purkinje networks.

Damage to any of the conducting cells in or below the bundle of His is collectively referred to as "infra-Hisian blocks".

Infra-hisian blocks limit the heart's ability to coordinate the activities of the atria and ventricles, which usually results in a decrease in its efficiency in pumping blood.

[3] These specialized muscle fibers in the heart were named after the Swiss cardiologist Wilhelm His Jr., who discovered them in 1893.