Cryptandra spinescens is a species of flowering plant in the family Rhamnaceae and is endemic to New South Wales.

It is a straggling, much-branched shrub with spiny side-branches, egg-shaped to lance-shaped leaves, and spike-like clusters of white, tube-shaped flowers.

Cryptandra spinescens is a straggling, much-branched shrub that typically grows to a height of up to 1 m (3 ft 3 in), its side branches less than 10 mm (0.39 in) long and ending in a sharp spine.

[2][3] Cryptandra spinescens was first formally described in 1825 by Augustin Pyramus de Candolle in Prodromus Systematis Naturalis Regni Vegetabilis from an unpublished description by Franz Sieber.

[5] This cryptandra usually grows in open forest, often in rocky places, on the coast and nearby ranges between the Hunter Valley, Bungonia National Park and Tullibigeal in eastern New South Wales.