Grounds for this change had been somewhat prepared previously by a short-lived spin-off strip called "That's Our Granny" which established that the two boys shared a grandmother.
The characters took over the front page of The Dandy from issue 3008 (July 1999) until October 2000, when they got 'thrown out' for misbehaving too much (in reality, readers wanted Desperate Dan back on the cover).
By the time of the revamp in October 2004, Cuddles and Dimples were assigned to Nigel Parkinson to freshen up their look (prior to the new look, the strip had been reprinted since early 2004).
Their parents were also revamped, dad being a pot-bellied balding idiot and mum an up-to-date babe or a yummy mummy.
The strip was axed with The Dandy's revamp in October 2010; however, they returned in reprints from February 2012 onwards.