[1] Anterior sacral meningocele is the most common presacral mass in patients with Currarino syndrome, occurring in 60% of cases.

[4] The disorder is an autosomal dominant genetic trait[5] caused by a mutation in the HLXB9 homeobox gene.

In 2000 the first large series of Currarino cases was genetically screened for HLXB9 mutations, and it was shown that the gene is specifically causative for the syndrome, but not for other forms of sacral agenesis.

[7][8] Surgery of an anterior myelomeningocele is only indicated in the rare case in which the space-occupying aspect is expected to cause constipation or problems during pregnancy or delivery.

[10] By accurate evaluation, the correct surgical management, including neurosurgery, can be performed in a single-stage approach.