The series began airing in Japan in April 2018 and is licensed in North America by Sentai Filmworks.

When her father is killed by the evil Panther Claw organisation, Honey teams up with the PCIS (Panther Claw Criminal Investigative Services) to fight against them, unaware that its key investigator, Inspector Genet, is really Panther Claw's leader, Sister Jill.

[3] Cutie Honey Universe was first announced in December 2017 as part of creator Go Nagai's 50th anniversary as a manga artist.

[11][12] The anime is being directed by Akitoshi Yokoyama at Production Reed, with series composition by Natsuko Takahashi and character design and chief animation direction by Syuichi Iseki.

The series premiered in Japan on April 8, 2018 on AT-X, Tokyo MX and BS11.