[1] It lies south of Mindoro and between Northern Palawan and Panay.

It is centered on the largest island of the archipelago, Cuyo Island, with an area of 22 square miles (57 km2) and is about 9 miles (14 km) long.

The 45 islands and islets of the archipelago form a total land area of 50 square miles (130 km2).

They are positioned on the western edge of the Luzon Arc.

The northern islands of Quiniluban seem to be uplifted coral atolls, although the heights of some of the peaks strongly suggest volcanic uplift.