The family of a famous Athenian lawyer of the time, who had recently lost their only child, helped Cybele's adoptive parents financially.

In 1908, she worked for the first time with Gregorios Xenopoulos, who wrote her the theatric play The Red Rock (Ο Κόκκινος Βράχος), based his short novel written of the same name.

In 1932, she joined forces with Marika Kotopouli, her "stage enemy", in order to compete the newly founded National Theater of Greece.

After the German invasion, she fled along with her husband, George Papandreou, and the Greek government and royal family to the Middle East.

After the war, she returned in Greece and performed various roles with the National Theater, accompanied by Ellie Lambeti, Dimitris Horn, Mitsos Myrat and other famous actors and actresses.