She and her sister, Virginia Moon are best known for their role as Confederate spies during the American Civil War.

"[1] As spies for the Confederacy, Lottie and Ginnie smuggled information and medicine from North to South.

[2] Before the American Civil War, Moon married Judge James Clark.

Various anecdotal incidents include spying on President Abraham Lincoln, passing herself off as a traveling British subject with forged papers, pretending to be in horrible pain due to a dislocated jaw, and hiding medicine and pain relievers in her quilted hoop skirts.

Moon began a second career as a journalist, eventually covering the Franco-Prussian War from various capitals in Europe.