[1] He has been opposed by Spider-Man, Scarlet Spider, Man-Thing, Cyclops, Hulk, Juggernaut, Doctor Strange, Cloak & Dagger, and the New Avengers.

The character was portrayed by Brooklyn McLinn in the second season of the Marvel Cinematic Universe television series Cloak & Dagger.

[12] With their powers combined, the Fear Lords (except for the Straw Man who opposes their plan) believe that they can plunge humanity into a permanent state of terror.

[15] D'Spayre attempts to enhance his power by using a Cosmic Cube to draw on the grief of the general public in the aftermath of Captain America's assassination following the "Civil War"[16] only for his use of the Cosmic Cube to have an apparently unintended side-effect when it granted the 'wish' of those who wanted Captain America back by drawing the Invaders into the present.

He has a vulnerability to physical harm when weakened by lack of psychic sustenance, and his powers rely on people hearing his words, allowing the deaf Echo to defeat him.

An adapted depiction of D'Spayre appeared in the second season of the live-action Marvel Cinematic Universe television series Cloak & Dagger, portrayed by Brooklyn McLinn.

[2] This version is Andre Deschaine, a former jazz musician who gave up his career due to developing severe headaches after a performance in which he attempted to hit a special "blue note".

After being exposed to the energies that were released, Deschaine gained the ability to drain people's hopes, which allow him to feed off of their despair to relieve his headaches.

[21] To provide himself with victims, he established a kidnapping and sex trafficking ring with a "community center" serving as a front,[22] and hired Lia Dewan, a nurse he met and coerced into joining him while in the hospital following the explosion, as his assistant.

[21] He eventually unlocks his veve, enters the Loa Dimension, and becomes D'Spayre, but is followed by Johnson and Bowen, with earthly assistance from Mayhem and Voodoo priestess Evita.