[1][8] He traveled extensively to lecture on subjects such as "ethics, religious-political extremism, church-state separation, skepticism and science advocacy".

[10][11] Grothe succeeded Phil Plait as president of the James Randi Educational Foundation (JREF) and served in that capacity from January 1, 2010, until September 1, 2014.

[14] Guests on For Good Reason included James Randi on the importance of JREF programs, Daniel Loxton on a book about evolution for children, Jamy Ian Swiss on psychics and their deceptive methods, the social psychologist Carol Tavris talking about dissonance theory, and Richard Dawkins talking about Darwin Day and creation and evolution in public education, among dozens of other guests he has interviewed.

[14] Grothe challenged celebrity psychic James Van Praagh to prove his claims of psychic mediumship and communication with the dead a number of times in the news media,[15] and organized a "zombie attack" featuring volunteers from the James Randi Educational Foundation of one of Van Praagh's "Spirit Circles", which net Van Praagh thousands of dollars from his clients seeking communication with their deceased loved ones.

Grothe has also spoken out against celebrity psychics Theresa Caputo (the Long Island Medium) and John Edward, criticizing them for taking advantage of the grieving by using a collection of psychological manipulations commonly referred to as cold reading, and has also criticized companies like Priceline.com and national media figures such as Dr. Phil for giving a platform to such psychic performers.