[3] Former guests include leading scientists, writers and public intellectuals such as Neil DeGrasse Tyson, Paul Krugman, Lisa Randall, Brian Greene, Oliver Sacks, Susan Jacoby, David Brin and Temple Grandin.

[4] iTunes features over 200 free episodes of Point of Inquiry, averaging 30 to 35 minutes in length, with each consisting of a long form interview with a high-profile guest from the worlds of scientific skepticism, science, academia, and philosophy.

The show focuses on traditional topics in scientific skepticism, such as psychic investigations, alternative medicine, alleged extraterrestrial visitations, ghosts, and cryptozoology.

[5] In July 2012, Point of Inquiry produced their first video episode featuring Michael De Dora, Ed Brayton, Jessica Ahlquist, and Jamie Kilstein.

[7] In October 2013, CFI announced the "new team who will take Point of Inquiry into its next exciting phase", Lindsay Beyerstein, Josh Zepps and producer Joshua Billingsley.