Being a generic system, D6 Adventure contains no setting information, and provides rules material for playing in a wide variety of modern or near-modern cinematic settings, including action adventure, pulp, espionage, western, and low-powered superhero games.

West End Games has released one world book for D6 Adventures, a reworking of the Masterbook title Bloodshadows.

Modern and pulp-era equipment is presented in D6 Adventure, and firearms are covered in more specific detail than in D6 Space.

Eric J. Gibson reworked the D6 System into a more generic rules system, as the third iteration of West End Games published a series of three core hardcover books, D6 Adventure (2004), D6 Fantasy (2004) and D6 Space (2004), and supplements to these genre books focusing on creatures and locations were published in 2004 and 2005.

This was greatly expanded and revised by author Nikola Vrtis into the current D6 Adventure Rulebook (ISBN 1-932867-00-7), released in 2004 by Purgatory Publishing imprint West End Games.