In human, DEPTOR gene locates at chromosome 8, 8q24.12 with protein size 409 a.a.[6] Human DEPTOR contains two N-terminal DEP domains and a C-terminal PDZ domain.

[7] DEPTOR is involved in mTOR signaling pathway as an endogenous regulator.

[8] In the muscle, Baf60c promotes a switch from oxidative to glycolytic myofiber type through DEPTOR-mediated Akt/PKB activation.

[9] Within the brain, DEPTOR is highly expressed in the hippocampus, the medio-basal hypothalamus and the circumventricular organs.

[10] Overexpression of DEPTOR in the medio-basal hypothalamus protects mice against high-fat diet-induced obesity by modulating Akt/PKB signaling.