175813406ENSG00000152592ENSMUSG00000029307Q13316O55188NM_001079911NM_004407NM_016779NM_001359013NP_001073380NP_004398NP_058059NP_001345942Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene.

[5][6][7] Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family (other members being DSPP, IBSP, MEPE, and SPP1).

In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes.

Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia.

MANCERA1, T. JHALA2, S. WANG2, C. QIN2, R. D'SOUZA2, and Y. LU2, 1School of Dentistry, Meharry Medical College, Nashville, TN, 2Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX