DNA‐templated organic synthesis (DTS) is a way to control the reactivity of synthetic molecules by using nature's molarity‐based approach.
Historically, DTS was used as a model of prebiotic nucleic acid replication.
Now however, it is capable of translating DNA sequences into complex small‐molecule and polymer products of multistep organic synthesis.
BE3 and its later version, BE4 allow to change the nucleobase C to T and nucleobase G to A. ABE7 allows to change A-T base pairs into G-C base pairs.
The system works by rearranging the atoms in the target base pair and then tricking cells into fixing the other DNA strand to make the change permanent.