Sodium trimethylsilylpropanesulfonate (DSS) is the organosilicon compound with the formula (CH3)3SiCH2CH2CH2SO3−Na+.

A white, water-soluble solid, it is used as a chemical shift standard for proton NMR spectroscopy of aqueous solutions.

[1] The chemical shift, specifically the signal for the trimethylsilyl group, is relatively insensitive to pH.

Sodium trimethylsilyl propionate (TSP) is a related compound used as an NMR standard.

4,4-Dimethyl-4-silapentane-1-ammonium trifluoroacetate (DSA) has also been proposed as an alternative, to overcome certain drawbacks of DSS.