His third studio album, Blame It on Baby (2020) became his second to peak the chart and spawned the single "Rockstar" (featuring Roddy Ricch), which spent seven non-consecutive weeks atop the Billboard Hot 100 in the wake of that year's George Floyd protests.

In 2020, he guest performed on the remix of "Whats Poppin" by Jack Harlow and the single "Levitating" by Dua Lipa, both of which peaked at number two on the Billboard Hot 100.

[9] Once they started working together, the team kept building buzz around the South with mixtapes and club shows, while Kirk was finding his sound.

[11] Thanks to the guidance of Taylor, and following major label bidding wars, Kirk landed a seven-figure recording deal with Interscope.

[14] Kirk featured on various hit songs throughout mid-2019, including Megan Thee Stallion's "Cash Shit" and Quality Control's "Baby", both of which reached the top 40 on the Billboard Hot 100.

In July 2019, Kirk was featured on Dreamville's compilation album Revenge of the Dreamers III, on the opening track, "Under the Sun".

He received acclaim for his guest feature, with various publications ranking it as his best verse of 2019,[15][16][17] including Complex magazine calling it a "defining breakout moment for a new rap superstar".

Around that time, Kirk also made notable appearances on singles such as Post Malone's "Enemies",[20] which peaked at number 16 on the Billboard Hot 100, and on the remixes to YG's "Stop Snitchin", Lizzo's "Truth Hurts",[21] and Lil Nas X's "Panini",[22] released in May, August, and September 2019, respectively.

In October, he made a cameo appearance in the music video for his protégé, Rich Dunk's single "High School".

[28][29] In June, Kirk was featured on the remix for the Jack Harlow song "Whats Poppin", which peaked at number two on the Hot 100 while "Rockstar" was still at the top.

In January 2021, DaBaby released the single "Masterpiece" alongside a music video for the track directed by Gemini Visions.

[40][41] While performing at the Rolling Loud Festival in Miami Gardens, Florida on July 25, he said, "[If] you didn't show up today with HIV/AIDS, or any of them deadly sexually transmitted diseases that'll make you die in two to three weeks, then put a cellphone light in the air.

[46] On August 2, the organizers of the Governors Ball Music Festival announced Kirk had been removed from the 2021 lineup as a result of his comments.

[49] Radio stations substituted a version of the "Levitating" remix without his contribution, resulting in his credit being removed on the Billboard Airplay Charts on August 9.

[52] Billion Dollar Baby Entertainment is an American record label founded by DaBaby in 2017, based in Charlotte, North Carolina.

[8] Speaking on his influences, Kirk has said he studied artists like Future, Lil Wayne and Kanye West, who he says "came up and consistently progressed".

Jeff Weiss of The Guardian favorably compared to Kirk to Busta Rhymes, Eminem, Missy Elliott and Ludacris, noting the similarities in their musical styles which include "inventive rap stylists unafraid to make videos full of funny parodies and rubber-faced camera goofs".

If the charts are filled with opiated threnodies about addiction and sadness, he eschews singing in favor of raps that could take your head off".

Months after the split, it was reportedly confirmed that Kirk had fathered a child with her after a viral incident of the two was recorded and posted on Instagram.

[70] According to TMZ and other outlets, members of his crew allegedly assaulted and robbed a music promoter who only paid Kirk $20,000 of the $30,000 he was owed for a performance in Miami.

"[74] In February 2022, Kirk and his crew assaulted DaniLeigh's brother Brandon Bills at a bowling alley in the Los Angeles area.

[75] Later that year, Kirk was charged with felony battery for an alleged assault against a rental property owner in Los Angeles.