Dacarbazine, also known as imidazole carboxamide and sold under the brand name DTIC-Dome, is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma.

[8][9] Dacarbazine was proven to be just as efficacious as procarbazine,[10] another drug with similar chemistry, in the German trial for paediatric Hodgkin's lymphoma, without the teratogenic effects.

The Swedish National Board of Health and Welfare has sent out a black box warning and suggests avoiding dacarbazine due to liver problems.

[13] Dacarbazine is activated by liver microsomal enzymes to monomethyl triazeno imidazole carboxamide (MTIC), which is an alkylating compound.

There are generic versions of dacarbazine available from APP, Bedford, Mayne Pharma (Hospira) and Teva.