Selected in the third round of the 2010 NFL draft, he played in the league for the Tennessee Titans, Miami Dolphins, and St. Louis Rams.

Williams initially planned on attending the University of Florida, but, in February 2006, switched to Arkansas, joining three other star teammates who had already committed.

In mid-December, Williams' parents, along with those of two other freshmen, met with Arkansas athletic director Frank Broyles to raise concerns that their sons might not be a good fit for the Razorbacks' system when they had been used to a pass oriented, spread offense under Malzahn's tenure at Springdale.

On December 23, 2009, several sources reported that Williams, who had already graduated from USC, would enter the 2010 NFL draft, forgoing his final year of college football eligibility.

[8] Williams made his first career start against the Cleveland Browns on October 2, 2011, after the injury to Kenny Britt, who went down on September 25, 2011, tearing his ACL and MCL.

Damian made his first career NFL touchdown catch against the Cleveland Browns on October 2, 2011 from a pass thrown by Matt Hasselbeck.