[6] Dan Kwaku Botwe was born on February 26, 1958, in Abiriw-Akuapem,[7] located in the Eastern Region of Ghana.

[2][12] He has been described by President Akufo-Addo as "a heavy hitter, a political weight", for his achievement in taking the New Patriotic Party out of the opposition and into the government in 2001.

[14] Dan Botwe contested the parliamentary election in Okere in 2008 after the incumbent, Brandford Kwame Daniel Adu, had decided to step down as the constituency's parliamentarian.

He promised his support for Dreams FC, a Ghana Premier League team that plays their home game at Dawu, a town in his constituency.

The primaries were organized to find a replacement for John Agyekum Kufour, who had served his full term as the party's flag bearer and President of Ghana.

[17] Botwe had asserted that the flag bearer position needed a youthful person and should not be considered as a "retirement package" for the aged.

[12] From 2006 to 2007 Dan Botwe served as the Minister for Information (Ghana) in the John Agyekum Kufour administration.

[18][19] In January 2017, President Akufo-Addo named Dan Botwe as the Minister for the newly created Ministry of Regional Reorganization and Development.

[20] As a Cabinet minister, Dan Botwe is part of the inner circle of the president and will aid in key decision-making activities in the country.