Nicknamed the steroid guru, Duchaine gained worldwide notoriety due to his outspoken opinions on the use of performance-enhancing drugs, and made numerous television appearances discussing the subject on shows such as 20/20, Geraldo, and 60 Minutes.

One of their customers, however, was an undercover Food and Drug Administration (FDA) agent, and Duchaine was convicted a second time and sentenced to 36 months in prison.

In 1988 Robert Voy, the chief medical officer of the United States Olympic Committee (USOC), called it "a fabulous pharmacological text.

"[3] Both Voy and Don Catlin, the lead drug tester for USOC and the National Collegiate Athletic Association in the 1980s, used the book as a reference.

[3] In 1992, after being released from prison for a second time, Duchaine began writing a monthly Q&A column called "Ask the Guru", in Bill Phillips' Muscle Media 2000 magazine.

By this time Duchaine had published several books in The Underground Steroid Handbook series (co-authored with Michael Zumpano), and referred to himself as a "Human Performance Theorist".