He is currently a Full Professor in the School of Computer Science at Tel Aviv University, and the CTO of Assembrix, a startup company in industrial 3D printing.

[2] He then spent three years as a research associate in the Computer Science Robotics Laboratory at Stanford University.

He returned to Tel Aviv University as a faculty member in 1996[3], where he established the Computational Geometry Lab.

Halperin's main field of research is computational geometry and its applications, which include robotics, automated manufacturing, algorithmic motion planning for individual robots and multi-robot teams, assembly planning, and 3D printing.

A major focus of his work has been in research and development of robust geometric software, in collaboration with a group of European universities and research institutes: the CGAL project and library, which has earned the SoCG "test of time" award.