Dandenong opened as one of the original stations on the Melbourne to Sale railway line.

[4] Trains beyond Dandenong were generally hauled by L class electric locomotives, and were principally used for passenger services and briquette traffic, using coal from the large open cut coal mines in the Latrobe Valley.

[12][13][14] During the 2017/2018 financial year, Dandenong was the twelfth-busiest station on Melbourne's metropolitan network, with almost 2.2 million passenger movements.

Future services: In addition to the current services, the PTV Network Development Plan proposes linking the Cranbourne and Pakenham lines to both the Sunbury line and the proposed Melbourne Airport rail link via the Metro Tunnel.

[20] Cranbourne Transit operates three bus routes to and from Dandenong station, under contract to Public Transport Victoria: Kinetic Melbourne operates one SmartBus route via Dandenong station, under contract to Public Transport Victoria: Ventura Bus Lines operates twenty routes via Dandenong station, under contract to Public Transport Victoria: V/Line operates two coach services to and from Dandenong station: