[1] Drouin opened on 1 March 1878, when the line was extended from Bunyip to Moe.

The station, like the township itself, was supposedly named after a Frenchman invented a chlorination process for the extraction of gold and metals from ore,[2] or an Aboriginal word meaning 'north wind'.

[1] The signal box at Drouin closed in February 1988, with the block post abolished, all fixed signals covered and lights extinguished.

[4] By October 1989, all former sidings and crossovers, and the associated overhead wire, were abolished, effectively leaving Drouin as a "through" station.

[5] During this time, it received Viclink purple station signage, the first station on the regional rail network to receive this signage.