[3] On January 10, 2020, Patrick announced on his show that the relationship with AT&T Sports for the live video broadcast would end in its current form, shortly after Super Bowl LIV.

AT&T's Audience Network, which had simulcast the program since 2009, was ceasing operations, and the show would also end streaming via B/R Live, following a short-run that began in 2019.

The show mainly features guests involved with American football and sometimes other sports, whether current or former athletes, coaches, commissioners or agents.

Sports, various network and cable stations, and reporters from local media sources covering the beat involving a team, player or league in the news at the time.

Patrick is known for his wry, irreverent interviews, often asking humorous hypothetical questions and occasionally, making bets with his guests.

It was often viewed as the signature program on the network at the time, primarily because of Patrick's high-profile at ESPN/ABC and his ability to attract well-known and popular guests.

The show often broadcast live at the Super Bowl site, during the week before the big game, and during ESPN The Weekend at Orlando, Florida.

During the 2 pm ET hour, Patrick was reunited with long-time SportsCenter co-anchor Keith Olbermann, marking the latter's return to ESPN, since his abrupt departure from the company in 1997.

However, earlier on July 12, the Chicago Sun-Times had reported that Patrick would continue in radio and launch a new nationally syndicated program via the Chicago-based Content Factory.

During his final shows, clips from memorable interviews were played during the bumper music before each segment, and Dan encouraged listeners to visit his website (www.danpatrick.com) in order to keep up with him in the future.

"[6] Guests who appeared on his final show included Bob Costas, MLB outfielder Ken Griffey Jr., former NFL players Jerry Rice and Joe Montana, and actor Will Ferrell, as Ron Burgundy.

The program initially began on outlets owned by Clear Channel, but has since expanded to many more stations across the United States, both live and tape-delayed depending on the market.

The show’s airing on NBCSN was subject to preemption by other sporting events, especially the Tour de France in July.

[9][10] After Patrick's and Rich Eisen's shows were dropped by Audience as of February 28, 2020, both moved briefly to YouTube (with Eisen also simulcast on NBCSN), before Patrick moved again on August 24, 2020 to Comcast-owned streaming service Peacock, simulcasting on both services for a week before permanently settling with Peacock.

The studio features several monitors, sports memorabilia, a basketball hoop, a pinball machine, a foosball table, a bar with 3 kegs and a golf simulator.

As of 2015, with the move of all NBC Sports operations to Stamford including Football Night, the show mainly originates from Milford.

On April 19, 2019, the show moved again to a larger location at 363 Naugatuck Avenue in Milford, which includes a basketball court and full kitchen.

Michael Wilbon, co-host of Pardon the Interruption, is the only regular guest from ESPN, appearing a handful of times per year.

Patrick will often mockingly speak to ESPN management directly while on air, in large part after discovering thoughts or news he has been able to divulge from guests appearing on his show are later found on ESPN programs or website, without giving credit or mentioning The Dan Patrick Show as their source.

Patrick is joined on the air by the "Danettes": executive producer Paul Pabst ("Paulie"); executive producer Todd "LVD" Fritz ("Fritzy"); director of operations Patrick O'Connor ("Seton"); and board ops chief Marvin "Small Hands" Prince.

[15] Patrick regularly chats with his crew about sports, and discussion will often break off into other topics, such as current events, entertainment, and their personal lives.

The Danettes are generally encouraged to speak honestly and share their actual opinions, with Patrick often carrying on with them in a conversational manner.

Patrick has acknowledged that he was influenced by Howard Stern when incorporating the members of his staff into the on-air aspects of the show.