He later worked with Gerhard Armauer Hansen, discovering the bacteria causing leprosy, and made Bergen a world centre of lepra research in the middle of the nineteenth century.
[2][3][4] With dermatologist Carl Wilhelm Boeck, he was co-author of an acclaimed study on lepra titled Om Spedalskhed (1847).
[5] In October 1849, he was named head physician of research at Lungegaard Hospital (Lungegaardshospitalet).
In 1859, German pathologist Rudolf Virchow visited Danielssen in Bergen in order to study lepra.
[8] The characteristic anesthesia of the extremity affected by untreated Leprosy is sometimes called as the "Danielssen's Sign" in his honor.