[2] Over the next fifteen years, Fowle printed and co-printed publications such as the American Magazine and Historical Chronicle and The Independent Advertiser.

Among its writers were Jonathan Mayhew, a controversial Congregationalist and the eventual founder of Unitarianism in America, and an outspoken critic of the Stamp Act.

Fowle and Rogers were the first to print the New Testament in the American Colonies, for Daniel Henchman, and the first printer to publish the revolutionary writings of Samuel Adams.

[11] On October 7, 1756, Fowle began publication of The New Hampshire Gazette,[12] at which time he took on an apprentice named Thomas Furber, a native of Portsmouth.

[11] Fowle took on his nephew Robert as a partner and employed him as the editor, while they also taught a slave on how to operate and maintain the printing press.

[14] Among the printing material Fowle brought with him to Portsmouth was a set of wood and metal cuts of emblems, which included one of the Crow and the Fox, which was used to adorn the heading of his newspaper.

Then the Royal Arms was used, however, as the revolution drew near and the spirit of independence became commonplace throughout the colonies, all signs of royalty steadily disappeared from newspapers and other such printings.

The Gazette announced that it would cease further publication because, like so many other printers, Fowle was unwilling to pay the burdensome stamp tax, which was forcing an increase in newspaper prices.

[15] The opening passage of the Gazette article read: We are now arrived at the Eve of that remarkable Day, which is appointed to be as fatal to almost all that is dear to us, as the Ides of March were to the life of Cesar.The Gazette article went on to reference the effect of the Stamp Act as an act of slavery and a threat to commerce, and that its enforcement would amount to nothing less than a loss of liberty.

After being warned to never publish articles reflecting upon the Congress or the cause for independence in such a manner he ceased printing the paper until his nephew Robert L. Fowle in effect revived it on May 22 at Exeter.

Before Fowle's death that year he sold the New Hampshire Gazette to two of his current apprentices, John Melcher and George Jerry Osborne.