[2] From 2015 to 2021, he served as Chief Executive Officer of Sidewalk Labs, a startup company he helped found, focused on technology for city life.

[3][4] Previously, he was the CEO and President of Bloomberg L.P.,[5] Deputy Mayor For Economic Development and Rebuilding for New York City under Mike Bloomberg from January 2002 to December 31, 2007, led New York City's bid for the 2008 and 2012 Summer Olympics,[6][7] and was a managing partner at Oak Hill Capital Partners, a private equity investment firm.

[13] In 1994, after attending a World Cup soccer match between Italy and Bulgaria, Doctoroff was inspired to bring such competition to New York City as host of the 2008 Olympic games.

[14] Although London was ultimately selected to host the 2012 summer games, Doctoroff's Olympic efforts helped catalyze longstanding infrastructure and development projects in New York such as the extension of the No.

[15] As a result of his involvement with NYC2012, Doctoroff was asked to join the Bloomberg administration in late 2001 as deputy mayor for economic development and rebuilding.

[7] During his first term as deputy mayor, Doctoroff continued to focus on developing neglected areas of the cities Five-Borough Economic Opportunity Plan.

[20] In December 2012, he argued the changes made as a result of PlaNYC helped prevent further damage to the city from Hurricane Sandy, particularly in areas designated as flood zones.

[23] Congestion pricing was eventually dismissed by New York state legislators in April 2008, claiming the fee was unfair to middle-class commuters who did not have access to mass transit.

Under Doctoroff's leadership, Bloomberg L.P. shifted its focus from providing financial information and analysis to its network of Terminal subscribers, to building a news organization targeted to a broader business audience.

[33] In 2015, Doctoroff and Google formed a start-up called Sidewalk Labs, focused on developing technology to improve urban life.

[37] In December 2021, Doctoroff announced he was resigning as CEO as a result of developing symptoms that align with amyotrophic lateral sclerosis (ALS), from which his father and uncle died.

[38] In February 2013, Doctoroff announced that he was working with Mike Bloomberg and Carlyle Group co-founder David Rubenstein to put together a $25 million donation to support research for finding a cure to Amyotrophic lateral sclerosis (ALS).

[39] In 2013, Doctoroff became President and Chairman of a non-profit organization created to build a new arts facility at Hudson Yards, originally known as Culture Shed.

During his term as Deputy Mayor, Doctoroff led the process of site preservation for The Shed as part of the redevelopment of Manhattan's Far West Side.

[42] In late 2021, Doctoroff announced his own diagnosis with ALS, stating that he would "dedicate my life to battling this disease," beginning with a new $250 million fundraising effort.