Daniel R. Mulville (born 1939) is an American engineer who served briefly as Acting Administrator of NASA in 2001.

[6] From 1986 to 1990, Mulville was Deputy Director of the Materials and Structures Division in the Office of Aeronautics and Space Technology, NASA Headquarters.

[6] From 1990 to 1994, Mulville was Director of the Engineering and Quality Management Division in the Office of Safety and Mission Assurance, NASA Headquarters.

He served briefly as acting Administrator of NASA, starting on November 19, 2001, as the result of the resignation of Daniel Goldin.

He oversaw NASA's daily operations until the new administrator, Sean O'Keefe was confirmed by the United States Senate on December 21, 2001.