The Deputy Administrator of the National Aeronautics and Space Administration is the second-highest-ranking official of NASA, the national space agency of the United States.

Administrator of NASA is NASA's chief decision maker, responsible for providing clarity to the agency's vision and serving as a source of internal leadership within NASA.

The office holder also has an important place within United States space policy.

[2] The longest-running (acting) Deputy Administrator was John R. Dailey, who held the post following his retirement from the United States Marine Corps.

[7] The current Deputy Administrator is Pamela Melroy, who was confirmed by the Senate on June 17, 2021, and sworn in on June 21, 2021.