His main output was as an engraver and publisher, however, producing a large number of historical, topographical, and ornamental prints.

[4][1] Orme is particularly known for his images of contemporary military heroes, including Captain John Hunter, Admiral Richard Howe, and Horatio Nelson.

[5] In October 1814 Orme returned to Manchester, where he gave lessons in drawing, etching, and oil painting and continued to work as a portrait painter.

[9] Orme married Ann Barr at St George's Church in Hanover Square on 25 June 1787.

He sketched himself and one of his daughters attending an archery day held at the Duke of Devonshire's residence in Derbyshire, Chatsworth, in 1823.