It displays many features found in the Greek Revival style of architecture, including: low-pitch gable ends, fluted pilaster corner boards, boxes cornice with dentils and a plain frieze, and a full-front porch with Doric columns.

In about 1870 a one-story clapboarded addition was made to the southwest corner of the house.

The Daniel Smith house is locally significant due to its association with Prescott, Wisconsin's early settlement and historical development.

The owners of the house between its construction in about 1855 and 1889 were instrumental in the establishment and support of many of the city's earliest commercial, civic, social, educational, governmental, and political activities.

The house was originally built for Daniel Smith, a local politician.