It is major east-west thoroughfare just south of Fort Myers city limits before becoming a north-south route through Lehigh Acres and Buckingham.

The east-west portion is locally known as Cypress Lake Drive west of U.S. Route 41 (Tamiami Trail) and Daniels Parkway east of there.

However, FDOT still maintains a 0.513 miles (0.83 km) portion of Daniels Parkway between the Interstate 75 interchange and the entrance to I-75's rest area.

Less than two miles later, Cypress Lake Drive intersects with Summerlin Road (CR 869) near the campus of Florida SouthWestern State College and it expands to six lanes.

In another mile, Cypress Lake Drive intersects with U.S. Route 41 (Tamiami Trail) near Bell Tower Shops.

Daniels Parkway continues east and crosses the Six Mile Cypress Slough as it approaches an interchange with Interstate 75.

Half a mile east of Interstate 75, Daniels Parkway intersects with Treeline Avenue (CR 885), which provides access to Southwest Florida International Airport.

Just west of Gateway, it passes JetBlue Park, the spring training home of the Boston Red Sox.

Two miles later, Gunnery Road intersects with Lee Boulevard (CR 884), the main east-west thoroughfare through Lehigh Acres.

[10] By the mid 1970s, Daniels Road was paved from US 41 up to the Ten Mile Canal and its crossing with the Seaboard Coast Line Railroad (the present-day Seminole Gulf Railway).