Born to a Jewish family,[1] Zuker graduated from Syracuse University in 1986, where he was a member of the Psi Upsilon fraternity.

[2][3] He is best known for his Emmy Award winning work as an executive producer of ABC's Modern Family.

[4] Zuker has worked in various capacities, on a variety of TV shows, including Just Shoot Me, Grace Under Fire, and Roseanne.

In May 2012, Zuker gave the keynote address at the graduation convocation of his alma mater, the S. I. Newhouse School of Public Communications.

[6] On April 15, 2019, Zuker joined a host of other writers in firing their agents as part of the WGA's stand against the ATA and the practice of packaging.