He is known for his role as Rufio, the leader of the Lost Boys in Steven Spielberg's Hook, Dolph in the cult film But I'm a Cheerleader, the lead character Ben Mercado in the independent film The Debut, and for voicing the titular protagonist of American Dragon: Jake Long and Prince Zuko in Avatar: The Last Airbender.

His voice acting roles include Zuko's grandson General Iroh II in The Legend of Korra, Quoc Wong in The Proud Family, Jingmei in The Boondocks, Tuck in Generator Rex, Scorpion in Ultimate Spider-Man, and Jai Kell in Star Wars Rebels.

His breakthrough performance was when he appeared as the leader Rufio of the Lost Boys in Steven Spielberg's 1991 film Hook with Robin Williams and Dustin Hoffman.

Basco and Janet Varney (voice of Korra) host the podcast, which follows them as they rewatch the series, discuss each episode's key moments and behind-the scenes information, and feature special guests.

Additional roles include Kwok Wong in The Proud Family, Matt Martin/Kewl Breeze in the short-lived animated series Zevo-3, and General Iroh in The Legend of Korra.