In 2020, He made his debut appearance with Bethel with the single "Champion" which was featured on the album Revival's in the Air.

Bowe also featured on several collaborations, most notably the song "Wait on You" alongside Elevation Worship, Maverick City Music and Chandler Moore.

[3] Bowe attributed the cultivation of his musical appreciation to his parents, and went on to develop a love for singing after participating in a seventh-grade talent show.

[3] Bowe's parents separated when he was eleven years old,[5] and at twelve, he found out that they were drug dealers in order to sustain their family.

[8] At sixteen, Bowe also had his spiritual awakening through the music of Kierra Sheard,[9] saying that the record Free (2011) had changed his life.

[10] In January 2017, Dante Bowe released his debut single, "Potter and Friend" featuring Jesse Cline.

[12] On January 11, 2019, Dante Bowe released "The Giant Is Dead" featuring Travis Greene, as a standalone single.

[32] Bowe alongside Chandler Moore featured on "Wait on You" by Elevation Worship and Maverick City Music, which was released as the third promotional single to their collaborative live album, Old Church Basement (2021), on April 23, 2021.

[41] Bowe ultimately won the Grammy Award for Best Contemporary Christian Music Album for his contribution on Old Church Basement at the 2022 ceremony.

[45] On May 13, 2022, Bowe announced that he will embark on his first headlining tour, dubbed the Worship Nights Tour, joined by fellow Maverick City Music member Aaron Moses and Aodhan King of Hillsong Young & Free and set to visit eight cities in the United States during the summer of 2022.

[46] Bowe and Crowder released "God Really Loves Us" featuring Maverick City Music as a single on June 3, 2022.

[49] On September 26, 2022, Maverick City Music announced via a statement published on Instagram that they will be pausing their professional relationship with Dante Bowe, citing behaviour that was inconsistent with their core values and beliefs,[50] the nature of which was not specified.

[51] Bowe released a statement stating that he would be taking a break from social media and expressed his commitment to God's purpose for his life.