Dardenne Prairie is a city in St. Charles County, Missouri, United States.

Dardenne Prairie is located southwest of O'Fallon on Missouri Route N, just east of I-64.

According to the United States Census Bureau, the city has a total area of 4.92 square miles (12.74 km2), all land.

[4] Dardenne is said to be a corruption of the French "Terre d'Inde", meaning the land of turkeys.

[6] "Turkey Land" on the other hand in French is Terre des Dindons[7] so the above explanation is not plausible.

A better explanation is that the name was borrowed from the Dardenne family, early pioneers in the Mississippi Valley.

[9] In the meticulous journal that William Clark kept on his trip west to establish Fort Osage in 1808 (only two years after returning from the Lewis and Clark Expedition), we find the first description of the prairie land around the Dardenne Creek area: August 25th "Set out from St. Charles, at half past 11 o'clock a.m., and proceeded on, passed Several branches of the Dardan Creek a branch of the Mississippi, through a Butifull high rolling Country interspersed with plains of high grass Most of them rich & fertile, and encamped at a pond at the out Skirts of the Settlement in a butifull Plain, near a few low trees.

[9] The 2020 United States census[11] counted 12,743 people, 4,585 households, and 3,941 families in Dardenne Prairie.

Of all households, 12.0% consisted of individuals and 7.5% had someone living alone who was 65 years of age or older.

10.8% of all households were made up of individuals, and 4.5% had someone living alone who was 65 years of age or older.

None of the families and 0.7% of the population were living below the poverty line, including no one under the age of 18 and 3.0% of those over 64.

Dardenne Prairie spans the Fort Zumwalt, Wentzville and Francis Howell School Districts.

Originally focusing in nursing and other allied health programs, a secondary building was opened in 2019, the Field to Table Institute, which specializes in culinary arts and agriculture as well as healthcare.