Her second and third marriages, to Alexander III and Vakhtang I, respectively in 1630 and 1661, made her a queen consort of Imereti, in western Georgia, where Darejan became embroiled in a series coups and counter-coups.

Darejan was a daughter of Teimuraz I of Kakheti and his second wife Khorashan, a sister of the neighboring Georgian monarch, Luarsab II of Kartli.

On this occasion, Teimuraz was presented with Shah Safi's decree confirmed him as a vassal king of Kartli and Kakheti, all of eastern Georgia.

Papuna, duke of Racha, urged Bagrat to employ the Ottoman force to remove Darejan, while the queen dowager enjoyed support of the catholicos Simon I.

Darejan then offered the crown to her father Teimuraz, who had been ousted from eastern Georgia by the Persians and was then living in the Skanda castle in Imereti.

During the turmoil Darejan and her husband became hostages of the Ottoman pasha of Akhaltsikhe and were placed under arrest in Oltu, from where she asked, via her Moscow-based nephew Nicholas, the tsar of Russia to intervene, but her pleas remained unanswered.

Following Chardin, Darejan's husband was held until the arrival of the blind Bagrat, the legitimate monarch, who had his hand guided as he stabbed the usurper repeatedly, exclaiming, "Traitor, you had my eyes put out; I shall tear out your heart!

"[6] Yet another 18th-century Georgian source, the anonymous Paris Chronicle, reports that Khosia Akhvlediani conspired with Prince Sekhnia Chkheidze to attack her while they were discussing state affairs in the presence of Bishop Sophron of Gelati.

Khosia wounded the queen in her breast with a musket shot, then tied her up and bribed the Turkish garrison soldiers to allow him to stab her to death in the castle gateway.