[2] The mechanism of action of darinaparsin is proposed to involve disruption of mitochondrial function, increased production of reactive oxygen species, and modulation of intracellular signal transduction pathways, thereby inducing cell cycle arrest and apoptosis in cancer cells.

It wasn't until 1998, when a connection between organoarsenic compounds and their potential use in cancer chemotherapy was reported, that interest in darinaparsin as a pharmaceutical drug began.

[4] In 2018, Solasia Pharma licensed Darinaparsin to HB Human BioScience SAS of Bogota Colombia.

[5] HB Human BioScience SAS began the registration process in Colombia, Peru, Ecuador, Venezuela, Chile, Panama, Costa Rica, and Guatemala, while offering Darinaparsin on a compassionate use (expanded access) basis.

[5] Darinaparsin was granted Orphan Drug Designation in the US and Europe as a treatment for peripheral T-cell lymphoma (PTCL).