He played college football at Tulane and was selected by the Chicago Bears in the fifth round of the 2020 NFL draft.

[9] In his NFL debut, a 27–23 victory over the Detroit Lions, Mooney caught three passes from Mitchell Trubisky for 38 yards.

[12] Week 17 against the rival Packers, Mooney had his best game of his rookie season, catching 11 passes for 93 yards.

[18] Mooney finished the 2023 Chicago Bears season with career lows of 31 receptions, 414 yards, one touchdown.

[20] In Week 5 against the Tampa Bay Buccaneers on Thursday Night Football, Mooney caught 9-of-16 targets for 105 yards and two touchdowns, marking the first multi-touchdown game of his career.