He played college football for the Minnesota Golden Gophers and was selected by Green Bay in the first round of the 1990 NFL draft with the 19th overall pick.

*indicates bowl stats included During his NFL career, Thompson played in 60 games as a fullback and tailback for the Green Bay Packers.

Thompson played alongside Brett Favre, Reggie White, LeRoy Butler and Sterling Sharpe.

Their oldest daughter, Dominique, played collegiate volleyball at University of Wisconsin–Madison and then professionally in Denmark for the 2015–2016 season.

Their other daughter, Indigo, plays collegiate volleyball at San Diego State University.