He signed with Villanova in April 2013 after considering Seton Hall, Utah, and South Carolina, choosing the Wildcats because he liked coach Jay Wright and the style of play.

[2] Reynolds played sparingly his freshman year, averaging 0.3 points and 1.0 rebounds in 3.1 minutes per game.

He began to see more playing time in the non-conference season of his sophomore campaign, contributing six points, four rebounds and two blocked shots in a matchup against Saint Joseph's.

[1] With Daniel Ochefu injured, Reynolds scored a career-high 19 points to go with 10 rebounds in a 72–60 win against Providence on February 6.

Reynolds's highest scoring game in Big East play was a 10-point effort in a victory over Xavier on January 10, 2017.

[1] He missed five games with a rib injury but returned for the regular-season finale against Georgetown, collecting seven rebounds and recording two steals in the 81–55 victory.

[10] Reynolds averaged 8.6 points, 7.2 rebounds, and 1.3 blocks per game as the team made the Polish Cup for the first time in their history.

While recuperating, he created the "Stay Tuned with D.Rey" talk show in which he interviewed Villanova basketball players, alumni and faculty.